Italian Sub Grilled Cheese

Featured in: Easy Prep Dishes

This Italian Sub Grilled Cheese combines the best of a classic Italian grinder with the comforting appeal of a melted cheese sandwich. Layers of salami, pepperoni, and creamy provolone are paired with a tangy lettuce mixture dressed in mayo, red wine vinegar, and oregano. Grilled until the bread turns golden and the cheese melts perfectly, this sandwich delivers authentic Italian-American flavors in just 20 minutes of prep and cooking time.

Updated on Fri, 23 Jan 2026 22:02:59 GMT
A close-up of a golden-brown Italian Sub Grilled Cheese, revealing melted provolone and layers of salami and pepperoni inside.  Save
A close-up of a golden-brown Italian Sub Grilled Cheese, revealing melted provolone and layers of salami and pepperoni inside. | dailykefta.com

The Italian Sub Grilled Cheese is a melty, savory sandwich that reimagines the classic cold cut grinder as a toasted masterpiece. Combining layers of salty salami and pepperoni with creamy provolone and a tangy, refreshing lettuce topping, this sandwich is grilled until golden and crispy for a satisfying meal that captures the essence of a deli favorite in every warm bite.

A close-up of a golden-brown Italian Sub Grilled Cheese, revealing melted provolone and layers of salami and pepperoni inside.  Save
A close-up of a golden-brown Italian Sub Grilled Cheese, revealing melted provolone and layers of salami and pepperoni inside. | dailykefta.com

This recipe is perfect for those who want a quick, hearty lunch or a flavorful weeknight dinner. By dressing the lettuce separately before adding it to the sandwich, you ensure every bite has that signature 'grinder' tang and crunch that makes the Italian sub so iconic.

Ingredients

  • 4 slices Italian bread or sturdy white sandwich bread
  • 2 tablespoons unsalted butter, softened
  • 4 slices provolone cheese
  • 6 slices salami
  • 6 slices pepperoni
  • 1 cup shredded iceberg lettuce
  • 2 tablespoons mayonnaise
  • 1 tablespoon red wine vinegar
  • 1 teaspoon dried oregano
  • Salt and freshly ground black pepper, to taste
  • 2 tablespoons mild pepperoncini rings, drained (optional)
  • 2 tablespoons thinly sliced red onion (optional)
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Instructions

Step 1
In a bowl, combine shredded lettuce, mayonnaise, red wine vinegar, oregano, salt, and pepper. Mix well. Set aside.
Step 2
Lay out the bread slices and spread one side of each with softened butter.
Step 3
Place two slices, buttered side down, on a work surface. Top each with 2 slices provolone, 3 slices salami, and 3 slices pepperoni.
Step 4
Add optional pepperoncini and red onion if desired.
Step 5
Spread the lettuce mixture evenly over the meats and cheese.
Step 6
Top each sandwich with the remaining bread slices, buttered side up.
Step 7
Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3–4 minutes per side, pressing gently, until bread is golden and cheese is melted.
Step 8
Remove from heat, slice in half, and serve hot.

Zusatztipps für die Zubereitung

For a spicier kick, add hot giardiniera or extra pepperoncini to the sandwich assembly before grilling.

Varianten und Anpassungen

Substitute whole wheat or sourdough bread if preferred, as both hold up well to the hearty meat and cheese fillings.

Serviervorschläge

Serve these hot sandwiches with a side of kettle chips or a simple tomato salad for a complete and balanced meal.

Two halves of a toasted Italian Sub Grilled Cheese on a checkered napkin, with shredded lettuce and a side of kettle chips.  Save
Two halves of a toasted Italian Sub Grilled Cheese on a checkered napkin, with shredded lettuce and a side of kettle chips. | dailykefta.com

With its combination of golden bread, melted cheese, and seasoned cold cuts, this Italian Sub Grilled Cheese is a crowd-pleasing twist on two classic sandwiches. Enjoy it immediately while the cheese is at its meltiest.

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Recipe FAQs

Can I make this sandwich ahead of time?

You can assemble the sandwich up to 2 hours ahead, but it's best to grill it fresh. If assembling early, store components separately and combine just before cooking to prevent the bread from becoming soggy.

What bread works best for this sandwich?

Sturdy Italian bread or thick-cut sandwich bread holds up best to grilling and melting cheese. You can also use sourdough or ciabatta for different textures. Avoid thin bread that may break apart.

How do I prevent the lettuce from wilting?

The lettuce will soften from heat, which adds texture. To keep it crispier, add the lettuce mixture to the sandwich just before grilling, or serve it on the side and add after cooking if you prefer.

Can I use different cured meats?

Absolutely. Capicola, mortadella, or prosciutto work wonderfully. Mix and match your favorite Italian cured meats in equal amounts. Just ensure you have about 6 slices of meat per sandwich for proper flavor balance.

What temperature should my skillet be?

Medium heat is ideal to prevent burning the bread while allowing time for the cheese to melt. The bread should take 3-4 minutes per side to turn golden. If your heat is too high, the outside browns before the cheese melts.

How can I make this sandwich spicier?

Add hot giardiniera, extra pepperoncini, or red pepper flakes to the lettuce mixture. You can also brush the bread with chili oil before grilling, or layer in sliced hot peppers for extra heat and flavor.

Italian Sub Grilled Cheese

Melty grilled sandwich featuring Italian cold cuts, provolone, and tangy lettuce topping. Golden and savory in just 20 minutes.

Prep Time
10 min
Time to Cook
10 min
Overall Time
20 min
Recipe by Harper Nelson


Skill Level Easy

Cuisine Italian-American

Portions 2 How Many Servings

Diet Preferences None specified

What You Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

Steps

Step 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded lettuce, mayonnaise, red wine vinegar, oregano, salt, and pepper. Mix thoroughly and set aside.

Step 02

Butter Bread Slices: Lay out all bread slices and spread one side of each with softened butter.

Step 03

Layer Base Ingredients: Place two bread slices buttered side down on a work surface. Top each with 2 slices provolone cheese, 3 slices salami, and 3 slices pepperoni.

Step 04

Add Optional Toppings: Distribute pepperoncini rings and red onion slices over the meats and cheese if desired.

Step 05

Distribute Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese layer.

Step 06

Complete Sandwiches: Top each sandwich with remaining bread slices, buttered side facing up.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 08

Serve: Remove from heat, slice sandwiches in half diagonally, and serve immediately while hot.

Tools Needed

  • Large skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy Info

Always review ingredients for potential allergens. When unsure, ask a healthcare expert.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs in mayonnaise—verify specific brand formulations
  • Contains pork from salami and pepperoni
  • Check all labels for potential trace allergens

Nutrition (each serving)

For info only—never a medical replacement. Please check with your provider if needed.
  • Energy (calories): 540
  • Fats: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g